DNA Replication Imaging Analysis

DNA Replication Imaging Analysis

As we all know, DNA is composed of two anti-parallel strands. The first step of DNA replication is to split the double helix into two single strands by helicase, then connect primers to the single strands and the replication starts, and then the DNA polymerase moves along the single strand to form new DNA. In all eukaryotes, DNA replication is a process that requires strict regulation, and it plays an important role in the maintenance and transmission of genetic information. Therefore, single-molecule imaging analysis is crucial to the study of DNA replication mechanisms.

The process of DNA replication.Figure 1. The process of DNA replication.

DNA Replication Imaging Analysis

In recent years, with the development of single-molecule imaging technology, researchers have a clearer understanding of the molecular mechanism of DNA replication. CD BioSciences has been committed to the research and development of fluorescent probes and living cell imaging technology for many years. We use single-molecule techniques such as electron microscopy and DNA fiber analysis to image and analyze DNA replication to study the dynamic behavior of a variety of biomolecules.

DNA Replication Imaging Analysis Workflow

The following are the specific steps of DNA replication imaging analysis:

Step 1

Fill in the online form to submit your requirements for DNA replication imaging analysis.

Step 2

Send us the DNA that need to be imaged and analyzed.

Step 3

We use single-molecule techniques such as electron microscopy and DNA fiber analysis to image and analyze DNA replication.

Step 4

After the experiment is completed, we will send the sample and experimental data to you.


Single-molecule imaging of double-stranded and single-stranded DNA
Exonuclease activity of a single DNA molecule
Number of double-stranded and single-stranded DNA
Quantitative analysis of the interaction between DNA and various enzymes
Provide other data according to your needs

Our Advantages

  • Real time monitoring of DNA-protein interactions
  • High spatial resolution, high signal-to-noise ratio
  • Visually analyze molecular interactions
  • Experienced scientists provide experimental consultation
  • Reasonable price and short turnaround time

CD BioSciences has a professional team and advanced imaging equipment. The entire process of DNA replication imaging analysis is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.

  1. Takahashi S, Oshige M, Katsura S. DNA Manipulation and Single-Molecule Imaging[J]. Molecules, 2021, 26(4): 1050.
  2. Chanou A, Hamperl S. Single-Molecule Techniques to Study Chromatin[J]. Frontiers in Cell and Developmental Biology, 2021, 9.

*If your organization requires the signing of a confidentiality agreement, please contact us by email.

Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!

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