Brain Imaging Services for Alzheimer's Disease (AD) Research
Services Overview
CD BioSciences offers a range of animal models for Alzheimer's disease research to support preclinical pharmacology studies and efficacy assessments. We combine these models with imaging and histology technologies to help researchers understand pathogenesis, assess drug efficacy, and identify potential treatments. Utilizing imaging techniques also allows for immunohistochemical assays to visualize markers associated with Alzheimer's disease. In addition, we provide non-invasive MRI/PET-CT imaging services for small animals to observe and assess brain function and pathology in real time and quantify neurodegenerative endpoints in Alzheimer's disease models.
Brain Imaging Services for Alzheimer's Disease (AD) Research
Animal models of Alzheimer's disease (AD)
CD BioSciences can provide a variety of high-quality rat/mouse animal models for Alzheimer's disease research to support preclinical pharmacological studies and drug efficacy evaluation. Combined with imaging and histology techniques, these models can help researchers better understand the pathogenesis of Alzheimer's disease, evaluate drug efficacy, and find potential treatments. Our experimental animal models of Alzheimer's disease include but are not limited to the following:
| Model | Modeling methods | Animal |
|---|---|---|
| Transgenic animal models (PS-1, PS-2, apoE4, etc.) | Through genetic engineering technology, genes related to Alzheimer's disease are introduced into animals to mimic the genetic variations of human Alzheimer's disease. | Rat / Mouse |
| Lesioning model | Surgical surgery to remove or damage the structure of the hippocampus of the brain to simulate the damaging effects of Alzheimer's disease. | Rat |
| Bilateral electrolytic basal forebrain model | Surgically insert electrodes into the brain and apply current stimulation to the basal ganglia region to simulate the pathological characteristics of Alzheimer's disease. | Rat |
| Ibotenic acid injection model | Injection of Ibotenic acid in the hippocampal region through brain localization induces damage and pathological changes. | Rat |
| Scopolamine injection model | Intraperitoneal injection of scopolamine leads to a decrease in CNS anticholinergic function, simulating cognitive and memory deficits in Alzheimer's disease. | Rat |
| Aβ injection model | Injection of β-amyloid (Aβ) solution into the hippocampal region of the brain mimics the pathological features of Aβ deposition in Alzheimer's disease | Rat |
| Gambogic acid injection model | Injection of gambogic acid into the brain stereotactically to study its potential effect in the treatment of Alzheimer's disease. | Rat |
| Cholinergic cell elimination model | Cholinergic cells in the basal forebrain are eliminated by immunotoxin injected into the brain to mimic the damaging effects of the cholinergic system in Alzheimer's disease. | Rat |
Immunohistochemical assay services for Alzheimer's disease (AD)
CD BioSciences offers immunohistochemical assays of Alzheimer's disease and visualization of markers using imaging technology. Helps clients gain insight into the pathological changes and neurological effects of Alzheimer's disease. The commonly used markers include:
- β-amyloid
Beta-amyloid is the main component in the formation of amyloid plaques in Alzheimer's disease. By using specific antibodies or radioactive tracers, beta-amyloid can be detected and imaged.
- Tau Protein
Tau protein is an important marker of neuronal degeneration, and techniques such as immunohistochemistry and immunofluorescence can be used to detect and observe changes in Tau protein.
- GFAP (Glial Fibrillary Acidic Protein)
GFAP is a glial cell-specific protein marker that can be used to detect glial cell changes in Alzheimer's disease.
- CHAT (Choline Acetyltransferase)
CHAT is a choline acetyltransferase that can be evaluated for changes in cholinergic neurons in Alzheimer's disease.
- TH (Tyrosine Hydroxylase)
TH is a key enzyme in dopaminergic and noradrenergic neurons and can be used in Alzheimer's disease to assess changes in these neurons.
- c-fos
c-fos is an immediate early gene that can be used as a marker of neuronal activity. Immunohistochemical detection of c-fos can be used to explore changes in neuronal activity in Alzheimer's disease research.
Animal live imaging analysis services
CD BioSciences also provides MRI/PET-CT in vivo imaging services for small animals. This non-invasive imaging technology enables real-time observation and evaluation of brain region function and pathological processes in animal models of Alzheimer's disease, generating high-resolution 3D images. The 3D imaging technology facilitates the quantification of multiple neurodegenerative endpoints in Alzheimer's disease, including beta-amyloid plaques and Tau protein fibril tangles.
CD BioSciences has a professional team and advanced imaging equipment. The whole process of brain imaging services for Alzheimer's disease (AD) research is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.
*If your organization requires the signing of a confidentiality agreement, please contact us by email.
Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!